Formulated with a high-potency blend of bioactive B vitamins, key methyl donors, and supportive amino acids designed to optimize methylation, homocysteine metabolism, and cellular detoxification.

B vitamins are essential for hundreds of daily processes in the body, from producing energy and neurotransmitters to supporting digestion, detoxification, and hormonal balance. 

This formula provides methylated and phosphorylated forms—5-MTHF (Quatrefolic®), methylcobalamin (B12), pyridoxal-5-phosphate (B6), and riboflavin-5-phosphate (B2)—alongside trimethylglycine (TMG) and L-serine to deliver essential cofactors for those with increased methylation needs, sluggish detox pathways, or compromised nutrient absorption.

MethylB+ is ideal for anyone looking to support foundational health—particularly those experiencing fatigue, brain fog, mood imbalances, digestive issues, or elevated homocysteine levels. Due to its potency, we recommend starting with a lower dose—especially if you have MTHFR, COMT, or other methylation-related gene variants, or if you’ve experienced sensitivity to methylated nutrients. In some cases, it may be helpful to test for MTHFR, COMT, or MAOA polymorphisms, or work with a practitioner to determine if this formula is right for you.*

Test Details

Learn more about each test in this panel.

How the device works

Our FDA-cleared device makes collection quick and virtually painless.

Stick it on your arm, press a button, and in about five minutes, you’re done. No needle. No fuss.

Accessing your results

Once your sample reaches our lab, you’ll get your results in 2–3 business days. We’ll email you when they’re ready, and you can view them through your secure online portal.

Your report is easy to read and ready to share with your healthcare provider.

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Answer a few quick questions and we’ll match you with the PRYM test kit that best fits your goals, symptoms, and lifestyle.

Whether you’re checking in on your hormones, managing fatigue, or just want a clearer picture of your health, we’ve got you. No surprise bills. No hassle.

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